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Invitrogen™ NOTCH2NL Polyclonal Antibody

Catalog No. PIPA5121738
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200 μL
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PIPA5121738 20 μL
PIPA5119312 200 μL
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Catalog No. PIPA5121738 Supplier Invitrogen™ Supplier No. PA5121738
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Description

Rabbit Polyclonal Antibody

NOTCH2NL Polyclonal Antibody for Western Blot, IHC (P)

Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOTCH2NL
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene NOTCH2NL
Gene Accession No. Q7Z3S9
Gene Alias N2N; notch 2 N-terminal like; Notch homolog 2 N-terminal like protein; notch homolog 2 N-terminal-like protein; Notch homolog 2 N-terminal-like protein A; Notch homolog 2 N-terminal-like protein C; NOTCH2NL; NOTCH2NLA; NOTCH2NLC
Gene Symbols NOTCH2NL
Host Species Rabbit
Immunogen Recombinant protein Notch2 N-Terminal Like Protein.
Purification Method Antigen affinity chromatography, Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 388677
Target Species Bovine, Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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