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Invitrogen™ NOTCH2NL Polyclonal Antibody
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Catalog No. PIPA530986
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100 μL
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PIPA530986 100 μL
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Catalog No. PIPA530986 Supplier Invitrogen™ Supplier No. PA530986
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: THP-1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOTCH2NL
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene NOTCH2NL
Gene Accession No. Q7Z3S9
Gene Alias N2N; notch 2 N-terminal like; Notch homolog 2 N-terminal like protein; notch homolog 2 N-terminal-like protein; Notch homolog 2 N-terminal-like protein A; Notch homolog 2 N-terminal-like protein C; NOTCH2NL; NOTCH2NLA; NOTCH2NLC
Gene Symbols NOTCH2NL
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human NOTCH2NL. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 388677
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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