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Invitrogen™ NOTUM Polyclonal Antibody
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Catalog No. 01675838
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Catalog No. Quantity
01-675-838 100 μg
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Catalog No. 01-675-838 Supplier Invitrogen™ Supplier No. PA112858
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Description

Rabbit Polyclonal Antibody

A suggested positive control for this product is HepG2 cell lysate.

Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the a/beta-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOTUM
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.08% sodium azide
Gene NOTUM
Gene Accession No. Q6P988, Q8R116
Gene Alias [Wnt protein] O-palmitoleoyl-L-serine hydrolase; 5730593N15Rik; hNOTUM; NOTUM; notum pectinacetylesterase homolog; notum pectinacetylesterase homolog (Drosophila); NOTUM, palmitoleoyl-protein carboxylesterase; OK/SW-CL.30; Palmitoleoyl-protein carboxylesterase NOTUM; protein notum homolog; RGD1307119
Gene Symbols NOTUM
Host Species Rabbit
Immunogen Recombinant full-length notum protein from mouse.
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 147111, 77583
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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