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Invitrogen™ NOX4 Monoclonal Antibody (3H2G11)
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Catalog No. PIMA538585
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100 μg
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Catalog No. Quantity
PIMA538585 100 μg
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Catalog No. PIMA538585 Supplier Invitrogen™ Supplier No. MA538585
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Description

Mouse Monoclonal Antibody

This antibody has been tested in indirect ELISA.

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOX4
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3H2G11
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene Nox4
Gene Accession No. Q9NPH5
Gene Alias AI648021; kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX; KOX1; KOX-1; NADPH oxidase 4; NOX 4; NOX4; NOX-4; renal NAD(P)H-oxidase; RENOX; superoxide-generating NADPH oxidase 4
Gene Symbols Nox4
Host Species Mouse
Immunogen Purified recombinant fragment of human NOX4 (aa: 210-310) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 50507
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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