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Apexbio Technology LLC Avanafil 330784-47-9 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A43345.1

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Avanafil (CAS 330784-47-9) is a potent and highly selective inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 value of 5 2 nM and a Ki of 4 3 nM PDE5 is abundantly expressed in the corpus cavernosum where it modulates blood flow by regulating the hydrolysis of cGMP Avanafil acts by competitively binding to PDE5 thereby preventing cGMP breakdown and promoting vasodilation In preclinical studies avanafil enhanced penile erection in dose-dependent manners with ED200% values of 37 5 g/kg (intravenous plasma concentration 59 6 ng/ml) and 151 7 g/kg (duodenal) Avanafil is primarily utilized in research related to erectile dysfunction and vascular signal transduction

Catalog No. 50-000-93751


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