Invitrogen™ NPTX2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5111299

Catalog No. PIPA5111299

Description

Immunogen sequence: ELERQLLRKV AELEDEKSLL HNETSAHRQK TESTLNALLQ RVTELERGNS AFKSPDAFKV SLPLRTNYLY GKIKKTLP.

Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.

Specifications

• Antigen: NPTX2
• Classification: Polyclonal
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P47972
• Gene Symbols: NPTX2
• Immunogen: Recombinant Protein corresonding to Human NPTX2. Recombinant protein control fragment (Product #RP-103055).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Gene: NPTX2
• Gene Alias: apexin; Narp; neuro activity regulated petaxin; neuronal activity-regulated pentaxin; neuronal activity-regulated pentraxin; neuronal pentraxin 2; neuronal pentraxin II; Neuronal pentraxin-2; NP2; NP-II; Nptx2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4885
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov