Invitrogen™ NPTX2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIPA5111299	Invitrogen™ PA5111299	100 μL
PIPA5111466	Invitrogen™ PA5111466	100 μL

Description

Immunogen sequence: ELERQLLRKV AELEDEKSLL HNETSAHRQK TESTLNALLQ RVTELERGNS AFKSPDAFKV SLPLRTNYLY GKIKKTLP.

Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.

Specifications

• Antigen: NPTX2
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P47972
• Gene ID (Entrez): 4885
• Immunogen: Recombinant Protein corresonding to Human NPTX2. Recombinant protein control fragment (Product #RP-103055).
• Product Type: Antibody

• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Classification: Polyclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: NPTX2
• Gene Alias: apexin; Narp; neuro activity regulated petaxin; neuronal activity-regulated pentaxin; neuronal activity-regulated pentraxin; neuronal pentraxin 2; neuronal pentraxin II; Neuronal pentraxin-2; NP2; NP-II; Nptx2
• Gene Symbols: NPTX2
• Primary or Secondary: Primary
• Purification Method: Antigen Affinity Chromatography