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  6. NR2F6 Mouse anti-Human, Clone: 2H2B8, Proteintech 

NR2F6 Mouse anti-Human, Clone: 2H2B8, Proteintech
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Catalog No. 501736248 Shop All Proteintech Group Inc Products
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50-173-6248 150 μL
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Catalog No. 50-173-6248 Supplier Proteintech Group Inc Supplier No. 601172IG150UL
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Description

Mouse Monoclonal Antibody

Transcription factor predomitly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5′-AGGTCA-3′ direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintece of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).

Specifications

Antigen NR2F6
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2H2B8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene NR2F6
Gene Accession No. P10588
Gene Alias EAR 2, EAR2, ERBAL2, NR2F6, V erbA related protein 2
Gene Symbols NR2F6
Host Species Mouse
Immunogen NR2F6 Fusion Protein Ag7614
Purification Method Protein G
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2063
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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