NR3C1 Monoclonal Antibody (OTI7A11), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-1009	100 μL

Catalog No. 50-168-1009 Supplier OriGene Supplier No. TA806207

Description

Mouse Monoclonal Antibody

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance.

Specifications

• Antigen: NR3C1
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI7A11
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: NR3C1
• Gene Accession No.: P04150
• Gene Alias: GCCR, GCR, GCRST, GR, GRL
• Gene Symbols: NR3C1
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-265 of human NR3C1 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2908
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1