NRF2/NFE2L2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 163961AP150UL

Catalog No. 50-553-534

Description

Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription activator which plays a key role in protecting the cell from oxidative stress and inflammation. It is primarily localized in the cytoplasm under normal conditions, but under conditions of oxidative stress, Nrf2 migrates to the nucleus to upregulate expression of genes with ARE (antioxidant response elements) in the promoter region. The upregulated genes include those involved in cellular protection, drug transport, detoxification, and anti-oxidant defense. The protein is ubiquitously expressed in various tissues, with the highest levels found in kidney, muscle, lung, heart, liver, and brain.

Specifications

• Antigen: NRF2/NFE2L2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NFE2L2
• Gene Alias: HEBP1, NF E2 related factor 2, NFE2 related factor 2, NFE2L2, NRF2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18024, 4780, 83619
• Content And Storage: -20°C
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 0.47 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: O54968, Q16236, Q60795
• Gene Symbols: Nfe2l2
• Immunogen: NRF2, NFE2L2 Fusion Protein Ag9489
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG