NRG1 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 2C6D12, Proteintech

Catalog No.	Quantity
50-173-6915	150 μL

Catalog No. 50-173-6915 Supplier Proteintech Group Inc Supplier No. 664921IG150UL

Description

Mouse Monoclonal Antibody

The neuregulins are a family of ErbB/HER ligands encoded by four genes. Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.

Specifications

• Antigen: NRG1
• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Classification: Monoclonal
• Clone: 2C6D12
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: NRG1
• Gene Accession No.: P43322, Q02297
• Gene Alias: ARIA, GGF, GGF2, Glial growth factor, Heregulin, HGL, HRG, HRG1, HRGA, NDF, Neu differentiation factor, neuregulin 1, NRG1, Pro NRG1, SMDF
• Gene Symbols: NRG1
• Host Species: Mouse
• Immunogen: NRG1 Fusion Protein Ag0803
• Purification Method: Protein G
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 102164569, 112400, 211323, 3084
• Target Species: Human, Mouse, Pig, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1