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NSC 87877, Tocris Bioscience™

Catalog No. 261350
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Catalog No. Quantity
26-135-0 50 mg
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Catalog No. 26-135-0 Supplier R&D Systems Supplier No. 2613/50
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Description

Potent inhibitor of shp2 and shp1 PTP

Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

Chemical Identifiers

CAS 56990-57-9
Molecular Formula C19H13N3O7S2
Molecular Weight (g/mol) 459.447
InChI Key BIQBDHSYQMHHPU-CJLVFECKSA-N
Synonym 8-hydroxy-7-6-sulfo-naphthalen-2-ylazo-quinoline-5-sulfonic acid, 8-hydroxy-7-6-sulfo-2-naphthyl azo-5-quinolinesulfonic acid, ncistruc1_001562, ncistruc2_001738, 8-hydroxy-7-6-sulfonaphthalen-2-yl diazenyl-quinoline-5-sulfonic acid, 8-hydroxy-7-6-sulfonaphthalen-2-yl diazenyl quinoline-5-sulfonic acid, 8-hydroxy-7-e-6-sulfo-2-naphthyl azo quinoline-5-sulfonic acid, 7e-8-oxo-7-6-sulfonaphthalen-2-yl hydrazinylidene quinoline-5-sulfonic acid
PubChem CID 5459322
IUPAC Name (7E)-8-oxo-7-[(6-sulfonaphthalen-2-yl)hydrazinylidene]quinoline-5-sulfonic acid
SMILES C1=CC2=C(C(=O)C(=NNC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)O)C=C2S(=O)(=O)O)N=C1

Specifications

Quantity 50 mg
Formula Weight 459.45
Percent Purity >98%
Chemical Name or Material NSC 87877

Safety and Handling

Recommended Storage Store at +4°C
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