Invitrogen™ NSG1 Polyclonal Antibody

Catalog No.	Quantity
PIPA5101719	100 μL

Catalog No. PIPA5101719

Supplier: Invitrogen™ PA5101719

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total NSG1.

NEEP21 (neuron-enriched endosomal 21kDa protein), also known as brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (Neurotensin receptor 2).

Specifications

• Antigen: NSG1
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: NSG1
• Gene Accession No.: P02683, P42857, Q62092
• Gene Alias: brain neuron cytoplasmic protein 1; brain neuron cytoplasmic protein 1/2; brain specific mRNA b; Bsmrb; carboxyterminally EE-tagged neuron-enriched endosomal 21 kDa protein; D4S234; D4S234E; m234; Neep21; neuron specific gene family member 1; Neuronal vesicle trafficking-associated protein 1; Neuron-enriched endosomal protein of 21 kDa; Neuron-specific protein family member 1; NSG1; p21; PEP1
• Gene Symbols: NSG1
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human NSG1(Accession P42857), corresponding to amino acid residues A111-V161.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18196, 25247, 27065
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov