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Invitrogen™ NSMCE1 Polyclonal Antibody

Catalog No. PIPA559625
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PIPA559625 100 μL
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Catalog No. PIPA559625 Supplier Invitrogen™ Supplier No. PA559625

Description

Rabbit Polyclonal Antibody

Immunogen sequence: RRMGVMTDVH RRFLQLLMTH GVLEEWDVKR LQTHCYKVHD RNATVDKLED FINNINSVLE SLYIEIKRGV TEDDGRPIYA LVN Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

The NSMCE1 (Non-SMC Element 1 Homolog) gene encodes a protein that is a key component of the SMC5-SMC6 complex, which is essential for DNA repair and the maintenance of genomic stability. Located on chromosome 16, the NSMCE1 protein interacts with other components of the SMC5-SMC6 complex, including SMC5, SMC6, and NSMCE2, facilitating the repair of DNA double-strand breaks and promoting chromosome segregation during cell division. NSMCE1 is particularly involved in homologous recombination, a critical pathway for error-free DNA repair. Mutations or deficiencies in NSMCE1 can lead to genomic instability, increased sensitivity to DNA-damaging agents, and have been associated with several genetic disorders and cancer predispositions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NSMCE1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NSMCE1
Gene Accession No. Q8WV22
Gene Alias 2510027N19Rik; HSPC333; HSPC337; Non-SMC element 1 homolog; non-SMC element 1 homolog (S. cerevisiae); non-structural maintenance of chromosomes element 1 homolog; NSE1; NSE1 homolog, SMC5-SMC6 complex component; Nsmce1; RGD1307760
Gene Symbols NSMCE1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human NSMCE1. Recombinant protein control fragment (Product #RP-98763).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 197370
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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