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Invitrogen™ NSMCE1 Polyclonal Antibody
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Catalog No. PIPA521820
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100 μL
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PIPA521820 100 μL
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Catalog No. PIPA521820 Supplier Invitrogen™ Supplier No. PA521820
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, Raji. Predicted reactivity: Mouse (90%), Rat (92%), Bovine (90%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The NSMCE1 (Non-SMC Element 1 Homolog) gene encodes a protein that is a key component of the SMC5-SMC6 complex, which is essential for DNA repair and the maintenance of genomic stability. Located on chromosome 16, the NSMCE1 protein interacts with other components of the SMC5-SMC6 complex, including SMC5, SMC6, and NSMCE2, facilitating the repair of DNA double-strand breaks and promoting chromosome segregation during cell division. NSMCE1 is particularly involved in homologous recombination, a critical pathway for error-free DNA repair. Mutations or deficiencies in NSMCE1 can lead to genomic instability, increased sensitivity to DNA-damaging agents, and have been associated with several genetic disorders and cancer predispositions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NSMCE1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene NSMCE1
Gene Accession No. Q8WV22
Gene Alias 2510027N19Rik; HSPC333; HSPC337; Non-SMC element 1 homolog; non-SMC element 1 homolog (S. cerevisiae); non-structural maintenance of chromosomes element 1 homolog; NSE1; NSE1 homolog, SMC5-SMC6 complex component; Nsmce1; RGD1307760
Gene Symbols NSMCE1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human NSMCE1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 197370
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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