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NT5E Monoclonal Antibody (OTI1G2), TrueMAB™, OriGene
SDP

Catalog No. 501682553
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50-168-2553 100 μL
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Catalog No. 50-168-2553 Supplier OriGene Supplier No. TA809085
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Description

Mouse Monoclonal Antibody

CD73 (Ecto-5-prime-nucleotidase, 5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. CD73 consists of a dimer of 2 identical 70 kDa subunits bound externally to the plasma membrane by a glycosyl phosphatidyl inositol linkage. CD73 is used as a marker of lymphocyte differentiation. Consequently, a deficiency of CD73 occurs in a variety of immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from CD73 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. The CD73 gene has been localized to 6q14-q21 by immunofluorescence and a study of a panel of human x mouse hybrids that contained fragments of chromosome 6 as translocations. Defects in the CD73 gene can lead to the calcification of joints and arteries, and intestinal tuberculosis. Two transcript variants encoding different isoforms of CD73 have been found.

Specifications

Antigen NT5E
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1G2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene NT5E
Gene Accession No. P21589
Gene Alias CALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT
Gene Symbols NT5E
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 119-232 of human NT5E produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4907
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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