Potent, selective PPARgamma partial agonist
Manufacturer: Tocris 2150/10
DescriptionPotent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC50 ~ 285nM). Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo.
- Chemical Name: 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
- Formula: C22H15Cl2NO2S
- CAS Number: 118414-59-8
- Solubility: Soluble to 100mM in DMSO
- Purity: >98