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Dojindo Molecular Technologies Inc Nucleolus Bright Red (60 NMOL) allows for high localization in nucleolus, simply add the reagent to fixed cells to measure the senescence marker.
Supplier: Dojindo Molecular Technologies Inc N51210
A Nucleolus is one of the structures forming a nucleus and becoming the starting point of the ribosomal biogenesis. There are many ribosomal RNA (rRNA) in the nucleolus and transcription of rRNA and processing are carried out. Whereas the morphological change of nucleolus is known as one of the indicators of cancer diagnosis, there have been some scientific reports describing the relation between nucleolus and DNA damage, autophagy, virus infection, and cellular senescence. Nucleolus Bright dyes are small molecules and they bind to RNA in the nucleolus to emit fluorescence. The nucleolus can be observed without any washing steps after staining with Nucleolus Bright dyes. We recommend to co-stain with DAPI in order to image the nucleolus clearly. Modern publications with a high number of citations summarize the various features of cellular senescence on the following page (https://www.dojindo.com/senescent-cell-detection-selection-guide/).
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