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NUMB Monoclonal Antibody (OTI4C6), TrueMAB™, OriGene
SDP

Catalog No. 501679126
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100 μL
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Catalog No. Quantity
50-167-9126 100 μL
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Catalog No. 50-167-9126 Supplier OriGene Supplier No. TA802157
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Description

Mouse Monoclonal Antibody

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.

Specifications

Antigen NUMB
Applications Western Blot
Classification Monoclonal
Clone OTI4C6
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene NUMB
Gene Accession No. P49757
Gene Alias C14orf41, S171, c14_5527
Gene Symbols NUMB
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 1-365 of human NUMB produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8650
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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