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Invitrogen™ NUP107 Polyclonal Antibody
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Catalog No. FEPA5144678
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FEPA5144678 100 μL
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Catalog No. FEPA5144678 Supplier Invitrogen™ Supplier No. PA5144678
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Description

Rabbit Polyclonal Antibody

Positive control: Hela cell lysate, 293T cell lysate, HepG2 cell lysate, Jurkat cell lysate, PC-3M cell lysate, A549 cell lysate, MCF-7 cell lysate, PC-12 cell lysate, RAW264.7 cell lysate, NIH/3T3 cell lysate, mouse testis tissue lysate. Predicted band size: 106 kDa Subcellular Location: Nucleus membrane, Nucleus, nuclear pore, Chromosome, centromere, kinetochore.

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP107 may be an important drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NUP107
Applications Western Blot
Classification Polyclonal
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene NUP107
Gene Accession No. P52590, P57740, Q8BH74
Gene Alias 107 kDa nucleoporin; AW541137; BcDNA.LD18761; BcDNA:LD18761; C76801; CG6743; CG6743-PA; Dmel\CG6743; Dmel_CG6743; dmNup107; NPHS11; nuclear pore complex; Nuclear pore complex protein Nup107; Nuclear pore complex protein Nup107-like protein; nucleoporin 107; Nucleoporin 107kD; nucleoporin 107kDa; nucleoporin Nup107; Nup; Nup 107; nup107; Nup107-PA; Nup170; NUP84; p105
Gene Symbols NUP107
Host Species Rabbit
Immunogen Recombinant protein within human aa 626-925/925.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 103468, 116555, 57122
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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