Invitrogen™ NUP88 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103980

Catalog No. PIPA5103980

Description

Antibody detects endogenous levels of total NUP88.

The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup88 (nucleoporin 88 kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex. Expressed ubiquitously, Nup88 is subject to phosphorylation by ATM or ATR and is upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis. The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1, 200 genes.

Specifications

• Antigen: NUP88
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NUP88
• Gene Alias: 88 kDa nuclear pore complex protein; 88 kDa nucleoporin; karyoporin; nuclear pore complex protein 88; nuclear pore complex protein Nup88; nucleoporin 88; nucleoporin 88kDa; nucleoporin Nup84; Nucleoporin Nup88; Nup84; NUP88; Prei2; preimplantation protein 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19069, 4927
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8CEC0, Q99567
• Gene Symbols: NUP88
• Immunogen: A synthesized peptide derived from human NUP88(Accession Q99567), corresponding to amino acid residues D436-T486.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov