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Apexbio Technology LLC LY2801653 1206799-15-6 100mg
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Supplier:  Apexbio Technology LLC A3573100

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LY2801653 (CAS 1206799-15-6) is an orally bioavailable small molecule inhibitor targeting the c-MET receptor tyrosine kinase with an IC50 of 2 nM c-MET also known as hepatocyte growth factor receptor (HGFR) mediates key cellular processes including proliferation survival and motility its dysregulation has been associated with tumor progression and metastasis LY2801653 acts as an ATP-competitive inhibitor of c-MET phosphorylation In vitro it fully inhibits HGF-induced cell scattering in DU-145 cells at concentrations from 0 01 to 10 M and shows greater antiproliferative effects in MET-expressing cell lines In vivo LY2801653 reduces apoptosis and angiogenesis in xenograft models supporting its utility in cancer research

Catalog No. 50-000-93739


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