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NVP BHG 712, Tocris Bioscience™

Catalog No. 44051
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Quantity:
1 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Potent EphB4 kinase inhibitor

Selective inhibitor of EphB4 kinase; exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. Also inhibits VEGF-induced angiogenesis in vivo; thought to inhibit EphB4 forward signaling. Orally active.

Chemical Identifiers

CAS 940310-85-0
Molecular Formula C26H20F3N7O
Molecular Weight (g/mol) 503.49
MDL Number MFCD20272929
InChI Key ZCCPLJOKGAACRT-UHFFFAOYSA-N
Synonym nvp-bhg712, 4-methyl-3-1-methyl-6-pyridin-3-yl-1h-pyrazolo 3,4-d pyrimidin-4-ylamino-n-3-trifluoromethyl phenyl benzamide, 4-methyl-3-1-methyl-6-3-pyridinyl-1h-pyrazolo 3,4-d pyrimidin-4-yl amino-n-3-trifluoromethyl phenyl benzamide, 4-methyl-3-1-methyl-6-pyridin-3-yl pyrazolo 3,4-d pyrimidin-4-yl amino-n-3-trifluoromethyl phenyl benzamide, 4-methyl-3-1-methyl-6-pyridin-3-yl-1h-pyrazolo 3,4-d pyrimidin-4-yl amino-n-3-trifluoromethyl phenyl benzamide, nvpbhg712, nvp-bhg712/, nvp-bhg hplc, , nvp bhg712
PubChem CID 16747388
IUPAC Name 4-methyl-3-{[1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-[3-(trifluoromethyl)phenyl]benzamide
SMILES CN1N=CC2=C(NC3=C(C)C=CC(=C3)C(=O)NC3=CC=CC(=C3)C(F)(F)F)N=C(N=C12)C1=CN=CC=C1

Specifications

Quantity 1 mg
Formula Weight 617.5
Percent Purity >98%
Chemical Name or Material NVP BHG 712
Recommended Storage Store at -20°C
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