Invitrogen™ O-linked N-acetylglucosamine (O-GlcNAc) Monoclonal Antibody (18B10.C7)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA1038

Catalog No. PIMA1038

Description

MA1-038 has been successfully used in Western blot and immunoprecipitation applications with human samples. In Western blot, MA1-038 detects proteins with O-GlcNAc post-translational modification, and therefore will detect multiple specific bands.

O-linked N-acetylglucosamine (O-GlcNAc) is a posttranslational modification characterized by the attachment of N-acetylglucosamine to specific serine or threonine residues. Unlike other protein glycosylations, O-GlcNAc modifications occur within the nucleus and cytoplasm. They are found on many cellular proteins, including nuclear pore, oncogene, cytoskeletal, heat shock, viral and transcription regulatory proteins. O-GlcNAc glycosylations are thought to obscure phosphorylation sites, counteracting phosphorylation-dependent signaling pathways and protein interactions.

Specifications

• Antigen: O-linked N-acetylglucosamine (O-GlcNAc)
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: O15294
• Gene Symbols: OGT
• Immunogen: SANM-conjugated linear peptide corresponding to human O-GlcNAc.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Chemical
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunoprecipitation, Western Blot
• Clone: 18B10.C7
• Conjugate: Unconjugated
• Gene: OGT
• Gene Alias: GlcNAc; HINCUT-1; HRNT1; O-GLCNAC; O-GlcNAc transferase p110 subunit; O-GlcNAc transferase subunit p110; OGT; O-linked N-acetylglucosamine (GlcNAc) transferase; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 8473
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid