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Invitrogen™ Occludin Polyclonal Antibody
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Catalog No. 422400
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Catalog No. Quantity
42-240-0 100 μg
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Catalog No. 42-240-0 Supplier Invitrogen™ Supplier No. 422400
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Description

Rabbit Polyclonal Antibody

Occludin Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.
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Specifications

Antigen Occludin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene OCLN
Gene Accession No. Q16625, Q28269
Gene Alias AI503564; BLCPMG; Occludin; occludin 1B; Ocl; Ocln; phosphatase 1, regulatory subunit 115; PPP1R115; tight junction protein occludin; tight junction structural protein
Gene Symbols OCLN
Host Species Rabbit
Immunogen Raised against the C-term of human Occludin.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100506658, 403844
Target Species Human, Canine
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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