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Invitrogen™ Occludin Recombinant Mouse Monoclonal Antibody (OC-3F10), Alexa Fluor™ Plus 488, Invitrogen™

Catalog No. p-200020368
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50 μL
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74-000-6MP488 50 μL
50-253-9570 20 μL
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Catalog No. 74-000-6MP488 Supplier Invitrogen™ Supplier No. 740006MP488
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Description

Mouse Recombinant Monoclonal Antibody

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Occludin
Applications Flow Cytometry, Immunocytochemistry
Classification Recombinant Monoclonal
Clone OC-3F10
Concentration 1.0 mg/mL
Conjugate Alexa Fluor Plus 488
Formulation Proprietary buffer with 0.008% Bromonitrodioxane, 0.008% Methylisothiazolone; pH 6.5
Gene OCLN
Gene Accession No. Q16625
Gene Alias AI503564; BLCPMG; Occludin; occludin 1B; Ocl; Ocln; phosphatase 1, regulatory subunit 115; PPP1R115; tight junction protein occludin; tight junction structural protein
Gene Symbols OCLN
Host Species Mouse
Immunogen GST fusion protein consisting of the C-terminal region (~150aa) of human occludin.
Purification Method Protein A/G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100506658
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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