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Apexbio Technology LLC A 205804 10MG
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Supplier:  Apexbio Technology LLC A866210

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A 205804 (CAS 251992-66-2) is a selective inhibitor targeting the expression of adhesion molecules E-selectin and ICAM-1 exhibiting IC50 values of 20 nM and 25 nM respectively E-selectin and ICAM-1 mediate endothelial-leukocyte interactions essential in inflammatory responses In human endothelial cell assays (e g HUVECs) A 205804 reduces ICAM-1 and E-selectin expression thus attenuating leukocyte-endothelial adhesion and migration Mechanistically A 205804 translocates to the nucleus binding non-covalently to large ( 650 kDa) molecular targets A 205804 serves as a research tool for studying inflammatory processes and adhesion-associated diseases

Catalog No. 50-000-60073


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