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Cayman Chemical Olaparib, 763113-22-0, MFCD13185161, 10mg
Supplier: Cayman Chemical 1062110
Molecular Formula: C24H23FN4O3, Formula Weight: 434.5, Purity ≥98%. Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 µM). It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.
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