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Oligomycin

Catalog No. AAJ61898MA
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Catalog No. AAJ61898MA Supplier Thermo Scientific Chemicals Supplier No. J61898MA
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Description

Oligomycin, CAS # 1404-19-9, is a macrolide antibiotic that inhibits oxidative phosphorylation through blocking mitochondrial ATP synthase. | CAS: 1404-19-9 | C45H74O11 | 791.08 g/mol

Inhibits respiration in mitochondria. Also inhibits ATP synthase

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Oligomycin is a macrolide produced by Streptomyces diastatochromogenes that is toxic to other organisms
  • Oligomycin blocks oxidative phosphorylation through inhibition of ATP synthase. The compound binds to the proton channel of ATP synthase and blocks mitochondrial proton import, resulting in accumulation of cytoplasmic protons
  • Oligomycin also inhibits Na+/K+ exchange through Na+ occlusion within the Na/K-ATPase
  • Oligomycin is provided as a mixture of A, B, and C isomers

Application

  • Oligomycin inhibits respiration in mitochondria. It also inhibits ATP synthase
  • Oligomycin can induce apoptosis in cultured human hepatocarcinoma and other mammalian cells in laboratory settings
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1404-19-9
Molecular Formula C45H74O11
Molecular Weight (g/mol) 791.08
MDL Number MFCD00065705,MFCD01779388
InChI Key MNULEGDCPYONBU-ZUSSGZTJNA-N
PubChem CID 78358496
IUPAC Name (4E,18E,20Z)-22-ethyl-7,11,14,15-tetrahydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethyl-2,26-dioxaspiro[bicyclo[23.3.1]nonacosane-27,2'-oxane]-4,18,20-triene-3,9,13-trione
SMILES CCC1CCC2OC3(CCC(C)C(CC(C)O)O3)C(C)C(OC(=O)\C=C\C(C)C(O)C(C)C(=O)C(C)C(O)C(C)C(=O)C(C)(O)C(O)C(C)C\C=C\C=C/1)C2C

Specifications

Type Oligomycin
Physical Form Powder
Color White
Quantity 10 mg
Beilstein 7615308
Merck Index 14,6833
Solubility Information Sparingly soluble in water; Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n
Formula Weight 791.07
Chemical Name or Material Oligomycin

Safety and Handling

EINECSNumber 215-767-9
RTECSNumber RK3325000
TSCA No
Recommended Storage Store at -20°C
SDS

RUO – Research Use Only

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