Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Oligomycin

Catalog No. AAJ61898MA
Click to view available options
Quantity:
10 mg

Oligomycin, CAS # 1404-19-9, is a macrolide antibiotic that inhibits oxidative phosphorylation through blocking mitochondrial ATP synthase. | CAS: 1404-19-9 | C45H74O11 | 791.08 g/mol

Inhibits respiration in mitochondria. Also inhibits ATP synthase

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Oligomycin is a macrolide produced by Streptomyces diastatochromogenes that is toxic to other organisms
  • Oligomycin blocks oxidative phosphorylation through inhibition of ATP synthase. The compound binds to the proton channel of ATP synthase and blocks mitochondrial proton import, resulting in accumulation of cytoplasmic protons
  • Oligomycin also inhibits Na+/K+ exchange through Na+ occlusion within the Na/K-ATPase
  • Oligomycin is provided as a mixture of A, B, and C isomers

Application

  • Oligomycin inhibits respiration in mitochondria. It also inhibits ATP synthase
  • Oligomycin can induce apoptosis in cultured human hepatocarcinoma and other mammalian cells in laboratory settings
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1404-19-9
Molecular Formula C45H74O11
Molecular Weight (g/mol) 791.08
MDL Number MFCD00065705,MFCD01779388
InChI Key MNULEGDCPYONBU-ZUSSGZTJNA-N
PubChem CID 78358496
IUPAC Name (4E,18E,20Z)-22-ethyl-7,11,14,15-tetrahydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethyl-2,26-dioxaspiro[bicyclo[23.3.1]nonacosane-27,2'-oxane]-4,18,20-triene-3,9,13-trione
SMILES CCC1CCC2OC3(CCC(C)C(CC(C)O)O3)C(C)C(OC(=O)\C=C\C(C)C(O)C(C)C(=O)C(C)C(O)C(C)C(=O)C(C)(O)C(O)C(C)C\C=C\C=C/1)C2C

Specifications

Type Oligomycin
Physical Form Powder
Color White
Quantity 10 mg
Beilstein 7615308
Merck Index 14,6833
Solubility Information Sparingly soluble in water; Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n
Formula Weight 791.07
Chemical Name or Material Oligomycin
EINECSNumber 215-767-9
RTECSNumber RK3325000
TSCA No
Recommended Storage Store at -20°C

RUO – Research Use Only

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.