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Selleck Chemical LLC Tamnorzatinib S8933-5MG
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Supplier:  Selleck Chemical LLC S89335MG

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Tamnorzatinib (ONO-7475) is a potent selective and orally active novel inhibitor of Anexelekto(Axl)/MER tyrosine kinase with IC50 of 0 7 nM and 1 0 nM for AXL and MER respectively ONO-7475 suppresses the emergence and maintenance of tolerant cells to the initial EGFR-TKIs osimertinib or dacomitinib in AXL-overexpressing EGFR-mutated NSCLC cells ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells

Catalog No. 50-217-3443


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