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Apexbio Technology LLC ONO-AE3-208 402473-54-5 25mg
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Supplier:  Apexbio Technology LLC A368425

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ONO-AE3-208 (CAS 402473-54-5) is a selective antagonist of the prostaglandin E2 receptor subtype EP4 a receptor implicated in inflammatory diseases and cancer progression particularly prostate cancer In cellular studies ONO-AE3-208 inhibits migration and invasion of prostate cancer cell lines (PC3 and LNCaP) reducing wound healing rates at 10 M and suppressing invasion in Transwell assays at 0 1 M In vivo the compound has been reported to limit bone metastasis of prostate cancer cells Additionally ONO-AE3-208 has been used in models of abdominal aortic aneurysm where it exhibits dose-dependent inhibition of elastin degradation and aneurysm formation

Catalog No. 50-000-96765


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