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Tocris Bioscience™ Opicapone
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Catalog No. p-7250125
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76-681-0 10 mg
76-685-0 50 mg
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Catalog No. 76-681-0 Supplier Tocris Bioscience™ Supplier No. 7668/10
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Description

COMT inhibitor

Opicapone is a reversible catechol O-methyltransferase inhibitor (COMT) inhibitor (IC50 = 224 nM). Decreases the ATP content and mitochondrial membrane potential in cells (IC50 values are 98 μM and 181 μM respectively). When administered with L-DOPA (Cat. No. 3788) it attenuates Parkinson's-like symptoms in an MPTP-induced animal model.

Specifications

Chemical Name or Material 5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol
CAS 923287-50-7
Quantity 10 mg
Target Catechol O-Methyltransferase (COMT) Inhibitors
Molecular Formula C15H10Cl2N4O6
Purity 0.98
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