Invitrogen™ Opsin 4 Polyclonal Antibody

Catalog No.	Quantity
PA1-781	100 μg

Catalog No. PA1-781 Supplier Invitrogen™ Supplier No. PA1781

Description

Rabbit Polyclonal Antibody

PA1-781 detects rat melanopsin. PA1-781 has been successfully used in Western blot, immunofluorescence, and immunocytochemistry procedures. By Western blot, this antibody detects ~53 and ~85 kDa proteins representing overexpressed unglycosylated and glycosylated melanopsin from HEK 293 cells (does not work well on endogenously expressed protein). By immunofluorescence and immunocytochemistry, PA1-781 detects melanopsin from rat retinal ganglion cells (RGCs). The PA1-781 immunogen is a synthetic peptide corresponding to residues E(455) Q K S K T P K T K R H L P S L D R R M(474) of rat melanopsin.

Melanopsin is an opsin-like protein found in the retinal ganglion cells of mammals. Melanopsin is believed to be part of a secondary optical system that parallels that of the classic rod and cone system. This second system reports directly to the suprachiasmatic nucleus and is responsible for regulation of circadian rhythms. Melanopsin is believed to be the primary photopigment responsible for the regulation of these circadian rhythms, and Melanopsin knockout mice have been generated which demonstrate decreased capacity to entrain to light and dark cycles.

Specifications

• Antigen: Opsin 4
• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene: OPN4
• Gene Accession No.: Q8R456
• Gene Alias: 1110007J02Rik; Gm533; LOC721663; Melanopsin; MGC142118; MOP; Mopn; OPN 4; OPN4; opn4 {ECO:0000312; opsin 4; opsin 4 (melanopsin); opsin-4; RGD:621701}
• Gene Symbols: OPN4
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues E(455) Q K S K T P K T K R H L P S L D R R M(474) of rat melanopsin.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 192223
• Target Species: Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG