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Invitrogen™ ORC1 Polyclonal Antibody
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Catalog No. PIPA582977
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100 μL
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PIPA582977 100 μL
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Catalog No. PIPA582977 Supplier Invitrogen™ Supplier No. PA582977
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YISGVPGTGK TATVHEVIRC LQQAAQANDV PPFQYIEVNG MKLTEPHQVY VQILQKLTGQ KATANHAAEL LAKQFCTRGS PQETTVLLVD E Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 93%.

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ORC1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Orc1
Gene Accession No. Q13415
Gene Alias AA545195; HS; HSORC1; MmORC1; orc1; orc1.L; Orc1l; origin recognition complex protein 1; origin recognition complex subunit 1; origin recognition complex subunit 1 L homeolog; origin recognition complex, subunit 1; origin recognition complex, subunit 1 homolog; origin recognition complex, subunit 1-like; PARC1; Replication control protein 1; XELAEV_18023178mg; xorc1
Gene Symbols Orc1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ORC1. Recombinant protein control fragment (Product #RP-94042).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4998
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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