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CPC Scientific H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 (trifluoroacetate salt) 1MG

Supplier: CPC Scientific OREX002B

Hypothalamic neuropeptide that regulates feeding behavior and significantly augments food intake in a dose-dependent manner when a bolus is administered intracerebroventricularly. After a 48-hour fast, hypothalamic prpro-orexin mRNA level is up-regulated 2.4. The discovery of orexins and their receptors may provide a novel molecular basis for understanding the role of the lateral hypothalamic areas in the regulation of energy homeostasis.SEQUENCE: H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 (trifluoroacetate salt)ONE-LETTER SEQUENCE: RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2MOLECULAR FORMULA: C123H212N44O35S1MOLECULAR WEIGHT: 2898.39STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [205640-91-1]SYNONYMS: Hypocretin-2 (human)RESEARCH AREA: ObesityREFERENCES:M.W. Schwartz, Nat. Med., 4, 385 (1998)T. Sakurai et al., Cell, 92, 573 (1998) SKU(s): OREX-002A, OREX-002B
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