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Invitrogen™ Osteopontin Monoclonal Antibody (7C5H12)
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Catalog No. PIMA517180
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100 μg
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PIMA517180 100 μg
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Catalog No. PIMA517180 Supplier Invitrogen™ Supplier No. MA517180
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Description

Mouse Monoclonal Antibody

MA5-17180 targets SPP1 in indirect ELISA, ICC, IHC, IF and WB applications and shows reactivity with Human samples. The MA5-17180 immunogen is purified recombinant fragment of human SPP1 (amino acids: 167-314) expressed in E. Coli. MA5-17180 detects SPP1 which has a predicted molecular weight of approximately 35.4kDa.

Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Osteopontin
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 7C5H12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene SPP1
Gene Accession No. P10451
Gene Alias 2AR; 2b7; 44 kDa bone phosphoprotein; Apl-1; BNSP; Bone sialoprotein 1; Bone sialoprotein 1 (BSPI/BSP1); Bsp; BSPI; Calcium oxalate crystal growth inhibitor protein; CALPHA1 fusion; Early T lymphocyte activation 1 (ETA1); early T-lymphocyte activation 1; early T-lymphocyte activation 1 protein; Eta; ETA-1; HGNC:11255; immunoglobulin alpha 1 heavy chain constant region fusion protein; MGC110940; Minopontin; nephropontin; Op; Opn; Opnl; OSP; osteopontin; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; osteopontin-like protein; PSEC0156; Ric; Secreted phosphoprotein 1; secreted phosphoprotein 1 (osteopontin bone sialoprotein I early T lymphocyte activation 1); secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); Secreted phosphoprotein 1 (SPP1); secreted phosphoprotein 1 variant 6; Sialoprotein (osteopontin); SPP1; SPP-1; SPP1/CALPHA1 fusion; unnamed protein product; urinar; urinary stone protein; Uropontin
Gene Symbols SPP1
Host Species Mouse
Immunogen Purified recombinant fragment of human SPP1 (amino acids: 167-314) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6696
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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