OTUD7B Monoclonal Antibody (OTI2E2), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-2835	100 μL

Catalog No. 50-168-2835 Supplier OriGene Supplier No. TA809496

Description

Mouse Monoclonal Antibody

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ′Lys-48′-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ′Lys-11′, ′Lys-48′ or ′Lys-63′- linked polyubiquitin chains. In vitro, has preference for ′Lys- 11′-linked polyubiquitin chains; however such data are unsure in vivo. Hydrolyzes both linear and branched forms of polyubiquitin.

Specifications

• Antigen: OTUD7B
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI2E2
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: OTUD7B
• Gene Accession No.: Q6GQQ9
• Gene Alias: CEZANNE, ZA20D1
• Gene Symbols: OTUD7B
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 449-729 of human OTUD7B produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 56957
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1