Invitrogen™ OX40L Monoclonal Antibody (OX89), PE

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA517913

Catalog No. PIMA517913

Description

MA5-17913 targets CD134L/OX40L in FACS, FN, and IHC applications and shows reactivity with Mouse samples. The MA5-17913 immunogen is cD4.CD134L chimeric protein.

The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.

Specifications

• Antigen: OX40L
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 4-5mg/mL BSA and 0.02% sodium azide
• Gene Accession No.: P43488
• Gene Symbols: Tnfsf4
• Immunogen: CD4.CD134L chimeric protein.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: OX89
• Conjugate: PE
• Gene: Tnfsf4
• Gene Alias: Ath1; Ath-1; atherosclerosis 1; CD134 ligand; CD134L; CD252; glycoprotein Gp34; GP34; OX40 antigen ligand; OX40 ligand; OX40L; OX-40L; OX4OL; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); tax-transcriptionally activated glycoprotein 1 ligand; TNFSF4; TNLG2B; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor (ligand) superfamily, member 4; tumor necrosis factor ligand 2B; tumor necrosis factor ligand superfamily member 4; tumor necrosis factor superfamily member 4; TXGP1; Txgp1l
• Host Species: Rat
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 22164
• Content And Storage: 4°C, do not freeze
• Form: Liquid