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Invitrogen™ P-cadherin Monoclonal Antibody (12H6), Alexa Fluor™ 488
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Catalog No. PIMA324A488
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50 μL
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Catalog No. Quantity
PIMA324A488 50 μL
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Catalog No. PIMA324A488 Supplier Invitrogen™ Supplier No. MA324000A488
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Description

Mouse Monoclonal Antibody

P-cadherin Monoclonal Antibody for ICC/IF

P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen P-cadherin
Applications Immunocytochemistry
Classification Monoclonal
Clone 12H6
Concentration 1 mg/mL
Conjugate Alexa Fluor 488
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene Cdh3
Gene Accession No. P22223
Gene Alias AI385538; CADH3; cadherin 15, M-cadherin (myotubule); cadherin 3; cadherin 3, type 1, P-cadherin (placental); cadherin-3; Cadp; calcium-dependent adhesion protein, placental; CDH3; CDHP; HJMD; PCAD; P-cadherin; Placental cadherin; Placental-cadherin; RPE-specific cadherin
Gene Symbols Cdh3
Host Species Mouse
Immunogen Human P-Cadherin fusion protein.
Purification Method Protein A
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1001
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1
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