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Invitrogen™ p130 Recombinant Rabbit Monoclonal Antibody (7H2L13)

Catalog No. 703847
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Catalog No. Quantity
70-384-7 100 μg
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Catalog No. 70-384-7 Supplier Invitrogen™ Supplier No. 703847
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Mouse, Rat, Bovine.

RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p130
Applications Western Blot
Classification Recombinant Monoclonal
Clone 7H2L13
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2-7.4
Gene RBL2
Gene Accession No. Q08999
Gene Alias 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RB transcriptional corepressor like 2; Rb2; rb2 p130; Rbl2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Gene Symbols RBL2
Host Species Rabbit
Immunogen Peptides corresponding to human p130 [1) aa175-aa192 2) aa1122-aa1139].
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5934
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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