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p130Cas Monoclonal Antibody (CAS-14 (35B-1A4)), Invitrogen™

Catalog No. PIMA514276
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PIMA514276 500 μL
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Catalog No. PIMA514276 Supplier Thermo Scientific Supplier No. MA514276
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Description

Mouse Monoclonal Antibody

MA5-14276 targets p130Cas in IHC (P), IP, and WB applications and shows reactivity with Human and Rat samples. The MA5-14276 immunogen is recombinant human p130Cas protein.

The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p130Cas
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone CAS-14 (35B-1A4)
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene BCAR1
Gene Accession No. P56945, Q63767
Gene Alias AI385681; BCA1; Bcar1; BCAR1 scaffold protein, Cas family member; BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; breast cancer anti-estrogen resistance 1; breast cancer anti-estrogen resistance protein 1; Cas; Cas scaffolding protein family member 1; CAS1; CASS1; CRKAS; CRK-associated substrate; Crk-associated substrate p130Cas; OTTHUMP00000174941; p130 Cas; P130CAS; p130Cas (pTyr410); p130Cas (pY410); p130Cas phospho; phospho p130Cas; v-crk-associated tyrosine kinase substrate
Gene Symbols BCAR1
Host Species Mouse
Immunogen Recombinant human p130Cas protein
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25414, 9564
Target Species Human, Rat
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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