p130Cas Monoclonal Antibody (CAS-14 (35B-1A4)), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA514276

Catalog No. PIMA514276

Description

MA5-14276 targets p130Cas in IHC (P), IP, and WB applications and shows reactivity with Human and Rat samples. The MA5-14276 immunogen is recombinant human p130Cas protein.

The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.

Specifications

• Antigen: p130Cas
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P56945, Q63767
• Gene Symbols: BCAR1
• Immunogen: Recombinant human p130Cas protein
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: CAS-14 (35B-1A4)
• Conjugate: Unconjugated
• Gene: BCAR1
• Gene Alias: AI385681; BCA1; Bcar1; BCAR1 scaffold protein, Cas family member; BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; breast cancer anti-estrogen resistance 1; breast cancer anti-estrogen resistance protein 1; Cas; Cas scaffolding protein family member 1; CAS1; CASS1; CRKAS; CRK-associated substrate; Crk-associated substrate p130Cas; OTTHUMP00000174941; p130 Cas; P130CAS; p130Cas (pTyr410); p130Cas (pY410); p130Cas phospho; phospho p130Cas; v-crk-associated tyrosine kinase substrate
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 25414, 9564
• Content And Storage: 4° C
• Form: Liquid

Safety and Handling

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