Invitrogen™ p19ARF Monoclonal Antibody (12-A1-1)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA116664

Catalog No. AMPA6664

Description

This antibody does not react with human or Golden Syrian hamster.

In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression.

Specifications

• Antigen: p19ARF
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.1% sodium azide
• Gene Accession No.: Q64364, Q8QZZ9
• Gene Symbols: Cdkn2a
• Immunogen: Synthetic peptide containing amino acids within 1-100 of the murine p19ARF.
• Regulatory Status: RUO
• Gene ID (Entrez): 12578, 25163
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 12-A1-1
• Conjugate: Unconjugated
• Gene: Cdkn2a
• Gene Alias: Alternative reading frame; Arf; ARF-INK4a; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; CDKN2A; cdkn2a {ECO:0000312; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; CMM2; cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3-like; cyclin-dependent kinase inhibitor protein; EMBL:AAL76336.1, ECO:0000312; EMBL:AAL76338.1, ECO:0000312; INK4; INK4A; Ink4a/Arf; INK4a-ARF; LOC100764983; mitochondrial smARF; MLM; MTS1; MTS-1; Multiple tumor suppressor 1; P14; P14ARF; p16; p16(INK4a); p16Cdkn2a; P16INK4; p16-INK4; P16INK4A; p16-INK4a; P19; p19>ARF>; p19ARF; Pctr1; RGD:2323}; TP16; Tumor suppressor ARF
• Host Species: Rat
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov