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P27/KIP1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. 501735434 Shop All Proteintech Group Inc Products
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50-173-5434 150 μL
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Catalog No. 50-173-5434 Supplier Proteintech Group Inc Supplier No. 267141AP150UL
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Description

Rabbit Polyclonal Antibody

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichiometry. p27 Kip1 has a molecular weight of approximately 27 kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Specifications

Antigen P27/KIP1
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.77 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene CDKN1B
Gene Accession No. P46414, P46527
Gene Alias CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27, P27; KIP1, P27KIP1
Gene Symbols CDKN1B
Host Species Rabbit
Immunogen P27; KIP1 Fusion Protein Ag25083
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1027, 12576
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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