Invitrogen™ p38 MAPK beta Monoclonal Antibody (P38-11A5)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 338700

Catalog No. 33-870-0

Description

33-8700 has been successfully used in immunofluorescence and western blot. 33-8700 specifically recognizes the beta isoform of p38, with slight reactivity to p38-gamma.

MAPK11 (p38 beta) is a serine/threonine kinase which is involved in a variety of cellular processes, and is activated by proinflammatory cytokines and environmental stress. Mitogen-activated protein kinase 11. The protein encoded by p38 MAPK beta is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.

Specifications

• Antigen: p38 MAPK beta
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: Q15759, Q9WUI1
• Gene Symbols: MAPK11
• Immunogen: Recombinant, full-length human p38 beta-2; the product of the p38-beta gene.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1, IgG2a

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: P38-11A5
• Conjugate: Unconjugated
• Gene: MAPK11
• Gene Alias: MAP kinase 11; MAP kinase p38 beta; MAPK 11; Mapk11; mitogen activated protein kinase 11; mitogen-activated protein kinase 11; Mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; OTTHUMP00000196655; p38-2; P38b; p38beta; P38BETA2; Prkm11; protein kinase, mitogen activated kinase, 11, p38beta; SAPK2; SAPK2b; Stress-activated protein kinase 2b; stress-activated protein kinase-2; stress-activated protein kinase-2b
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 19094, 5600
• Content And Storage: -20°C
• Form: Liquid