Invitrogen™ p53 (R175H Mutant) Recombinant Rabbit Monoclonal Antibody (HL1129)

Catalog No.	Quantity
PIMA546935	100 μL

Catalog No. PIMA546935 Supplier Invitrogen™ Supplier No. MA546935

Description

Rabbit Recombinant Monoclonal Antibody

Store as concentrated solution. Centrifuge briefly prior to opening vial.

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Specifications

• Antigen: p53 (R175H Mutant)
• Applications: Western Blot, Immunocytochemistry, Western Blot
• Classification: Recombinant Monoclonal
• Clone: HL1129
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene Accession No.: P29466, P48729, Q8N752
• Gene Alias: BCC7; BMFS5; LFS1; P53; TRP53; tumor protein p53
• Host Species: Rabbit
• Immunogen: Carrier-protein conjugated synthetic peptide surrounding mutant R175H of human p53. The exact sequence is proprietary.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 122011, 1452, 834
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG