P62/SQSTM1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 184201AP150UL

Catalog No. 50-553-750

Description

The molecular weight of p62 is predicted to be 48/ 38 kDa (depending on the isoform), while western blot analyses using this antibody detects the bands around 45-48 kDa and 60-62 kDa, respectively.

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Specifications

• Antigen: P62/SQSTM1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SQSTM1
• Gene Alias: P62, sequestosome 1, SQSTM1, Ubiquitin binding protein p62
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 113894, 18412, 8878
• Content And Storage: -20°C
• Form: Liquid

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
• Concentration: 0.29 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O08623, Q13501, Q64337
• Gene Symbols: Sqstm1
• Immunogen: P62/SQSTM1 Fusion Protein Ag13131
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG