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Invitrogen™ PABPC4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531940

Catalog No. PIPA531940


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Description

Description

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Human (99%), Mouse (96%), Rat (96%), Zebrafish (90%), Xenopus laevis (91%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PABPC4
Polyclonal
Unconjugated
PABPC4
Activated-platelet protein 1; APP1; APP-1; Inducible poly(A)-binding protein; iPABP; PABP4; PABP-4; PABPC4; poly(A) binding protein cytoplasmic 4; poly(A) binding protein, cytoplasmic 4; poly(A) binding protein, cytoplasmic 4 (inducible form); poly(A)-binding protein 4; polyadenylate-binding protein 4
Rabbit
Antigen affinity chromatography
RUO
230721, 8761
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.6 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Q13310
PABPC4
Recombinant protein fragment corresponding to a region within amino acids 18 and 229 of Human PABPC4.
100 μL
Primary
Human, Mouse
Antibody
IgG
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