Invitrogen™ PABPC4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531940

Catalog No. PIPA531940

Description

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Human (99%), Mouse (96%), Rat (96%), Zebrafish (90%), Xenopus laevis (91%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: PABPC4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PABPC4
• Gene Alias: Activated-platelet protein 1; APP1; APP-1; Inducible poly(A)-binding protein; iPABP; PABP4; PABP-4; PABPC4; poly(A) binding protein cytoplasmic 4; poly(A) binding protein, cytoplasmic 4; poly(A) binding protein, cytoplasmic 4 (inducible form); poly(A)-binding protein 4; polyadenylate-binding protein 4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 230721, 8761
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.6 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q13310
• Gene Symbols: PABPC4
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 18 and 229 of Human PABPC4.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG