Invitrogen™ PABPN1 Recombinant Rabbit Monoclonal Antibody (JM11-28)

Catalog No.	Quantity
PIMA532621	100 μL

Catalog No. PIMA532621 Supplier Invitrogen™ Supplier No. MA532621

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.

Specifications

• Antigen: PABPN1
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry, Western Blot
• Classification: Recombinant Monoclonal
• Clone: JM11-28
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
• Gene: PABPN1
• Gene Accession No.: Q86U42, Q8CCS6
• Gene Alias: mPABII; Nuclear poly(A)-binding protein 1; OPMD; PAB2; PABII; PABP2; PABP-2; Pabp3; PABPN1; poly(A) binding protein 2; poly(A) binding protein II; poly(A) binding protein nuclear 1; poly(A) binding protein, nuclear 1; poly(A)-binding protein 2; poly(A)-binding protein II; polyA binding protein II; polyadenylate-binding nuclear protein 1; Polyadenylate-binding protein 2
• Gene Symbols: PABPN1
• Host Species: Rabbit
• Immunogen: Synthetic peptide within Human PABPN1 aa 4-51.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 54196, 8106
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG