Invitrogen™ DUSP2 Monoclonal Antibody (PAC-1), FITC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA528564

Catalog No. PIMA528564

Description

This antibody recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation. Recommended dilution is for 100 μL of whole blood or 1x10^6 cells in suspension.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.

Specifications

• Antigen: DUSP2
• Classification: Monoclonal
• Conjugate: FITC
• Gene: DUSP2
• Gene Alias: dual specificity phosphatase 2; dual specificity protein phosphatase 2; Dual specificity protein phosphatase PAC-1; dual-specificity phosphatase 2; Dusp2; PAC1; Pac-1; serine/threonine specific protein phosphatase
• Host Species: Mouse
• Purification Method: Size-exclusion chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1844
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: PAC-1
• Formulation: TBS with 0.2% BSA and 15mM sodium azide; pH 8
• Gene Accession No.: Q05923
• Gene Symbols: DUSP2
• Immunogen: Human platelets.
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgM κ