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  6. Novus Biologicals™ Pam3CSK4, TLR1 and TLR2 Ligand

Novus Biologicals™ Pam3CSK4, TLR1 and TLR2 Ligand
SDP

Catalog No. NBP22529725 Shop All R&D Systems Products
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0.1 mg
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NBP22529725 0.025 mg
NBP225297 0.1 mg
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Catalog No. NBP22529725 Supplier Novus Biologicals™ Supplier No. NBP2252970.025MG
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Description

Applications: Functional, In vitro assay, In vivo assay, Ligand Activation

Pam3CSK4, TLR1 and TLR2 Ligand is a synthetic tripalmitoylated lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein. It activates monocytes and macrophages and is also a potent activator of proinflammatory transcription factor NF-kB. Pam3CSK4, TLR1 and TLR2 Ligand is recognized by a heterodimer formed between TLR1 and TLR2. Pam3CSK4, TLR1 and TLR2 Ligand stimulation: If your cell line does not naturally express TLR1+ TLR2, co-transfect with plasmids pCMV/TLR1and pCMV/TLR2. Forty-eight hours after transfection, stimulate cells with 10 to 100ng/ml of Pam3CSK4 for 6 to 24 hours. Determine Pam3CSK4 stimulation using appropriate detection assays. Buffer: Sterile water

Specifications

Concentration 0.5 mg/mL
Content And Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Quantity 0.025 mg
For Use With (Application) Activation of TLR1 and TLR2 heterodimer. Stimulation of TLR1 and TLR2 has been reported with 10 to 100ng/mL. Use in vitro assay reported in scientific literature (PMID: 24105263) Use in functional reported in scientific literature (PMID 25511699). Use in In-vivo reported in scientific literature (PMID 25466255). Use in ligand activation reported in multiple pieces scientific literature.
Target Pam3CSK4, TLR1 and TLR2 Ligand
Species Human/Mouse
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